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. Author manuscript; available in PMC: 2011 Oct 20.
Published in final edited form as: Bioconjug Chem. 2010 Oct 20;21(10):1820–1826. doi: 10.1021/bc100169y

Figure 1.

Figure 1

Schematic system design for immunocomplex capture and concentration under conditions of capture (>LCST) and release (<LCST). Covalently-modified pNIPAAm-antibody, bound antigen, and detection antibody are captured at membrane during polymer aggregation above the LCST, while unconjugated plasma components flow through. When the membrane region of the device is cooled, the polymer becomes hydrophilic and molecular conjugates are released back into the flow stream, carrying their cargo of antigen and detection antibody with them.