Table 2.
Pressure and oxygenation variables pre- and post L-arginine administration at 12 and 48 hours post-injury.
| Variable | 12 Hr Post-injury | 48 Hr Post-injury | P Value | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Pre-LA mean (SD) | Post-LA mean (SD) | Pre-LA mean (SD) | Post-LA mean (SD) | Day | L-Arg | Day x L-Arg | Day x L-Arg x Age | Other Factor | |
| ICP | 17.8 (9.7) | 17.8 (19.1) | 17.7 (8.7) | 17.7 (7.4) | 0.7713 | 0.7390 | 0.7779 | 0.7744 | |
| MAP | 90.4 (13.3) | 90.3 (13.4) | 95.6 (12.90) * | 93.6 (13.4) | 0.0225 | 0.7758 | 0.9919 | 0.7735 | |
| ETCO2 | 36.8 (5.8) | 36.7 (5.3) | 36.1 (5.9) | 37.6 (5.4) | 0.0932 | 0.7945 | 0.6085 | 0.1482 | Day x Age 0.0143 |
| pCO2 | 40.1 (6.1) | 40.2 (5.5) | 39.3 (5.4) | 39.8 (4.1) | 0.2274 | 0.6103 | 0.6233 | 0.2229 | Day x Age 0.0213 |
| SjvO2 | 73.6 (10.9) | 73.7 (10.1) | 73.2 (10.4) | 74.7 (10.0) | 0.9535 | 0.8136 | 0.7254 | 0.9067 | |
| PbtO2 | 24.5 (18.3) | 22.9 (19.6) | 22.0 (14.9) | 24.0 (18.3) | 0.99 | 0.8036 | 0.4106 | 0.5430 | |
*
= pre-L-arginine value at 48hr is different from pre-L-arginine value at 12hr (p<.05)
Abbreviations: LA = L-arginine infusion
L-Arg = effect of L-arginine administration
ICP = intracranial pressure
MAP = mean arterial pressure
ETCO2 = end-tidal carbon dioxide
pCO2 = arterial carbon dioxide pressure
SjvO2 = jugular venous oxygen saturation
PbtO2 = brain tissue pO2