Table 2.

Enrollment Scenarios: The four enrollment scenarios are characterized by a different distribution of subjects from each of the Groups defined by Kellgren-Lawrence (KL) score.

Enrollment scenario	(KL = 0)	(KL = 1)	(KL = 2)	(KL = 3)
1. Base Case: community equipoise	50%	10%	20%	20%
2. Selective enrollment of subjects with less severe OA	60%	30%	5%	5%
3. Selective enrollment of subjects with more severe OA	10%	10%	30%	50%
4. Highly selective enrollment of subjects with severe OA	5%	5%	20%	70%

See Table 1 for a description of the baseline and follow up WOMAC scores for each KL grade, both for surgically and nonoperatively treated subjects.