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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: J Clin Epidemiol. 2010 Jul 17;64(3):280–285. doi: 10.1016/j.jclinepi.2010.04.008

Table 3.

Summary results of 100 simulated trials performed for each for four enrollment scenarios.

Enrollment scenario % of simulated trials that cover true effect % simulated trials showing APM significantly better (empirical power) Mean RR (95% CI) for detecting clinically important difference
Community equipoise 100% 100% 1.87 (1.57, 2.14)
Selective enrollment of subjects with less severe OA 100% 100% 1.94 (1.68, 2.45)
Selective enrollment of subjects with more severe OA 46% 73% 1.45 (1.15, 1.93)
Highly selective enrollment of subjects with severe OA 25% 44% 1.34 (0.93, 2.15)