Fig. 5.

A representative experiment illustrating the effect of IL-1β on action potential frequency in the SLN. The bottom reading is a raw, digitised recording. The top trace illustrates the mean action potential frequency of a single unit (averaged over 10 s) and is derived from the raw recording. This graph is typical of the cytokine group of experiments. Application of increasing concentrations (low to high) of IL-1β does not alter the firing frequency of the SLN. The vigorous response to sodium cyanide (CN) elicited at the end of the protocol confirms the responsivity of the preparation.