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. 2010 Feb 26;37(4):492–502. doi: 10.1016/j.molcel.2010.01.021

Figure 5.

Figure 5

XRCC3 Promotes the Early Restart of Stalled Replication Forks

(A) Protein levels of XRCC3 and α-Tubulin (loading control) in U2OS cells after 48 hr depletion with control siRNA, pool of 4 XRCC3 siRNAs, or individual XRCC3 siRNAs #1 and #2. The asterisk denotes a nonspecific band.

(B) Representative images of replication tracks after restart from 2 hr HU treatment in control- and XRCC3-depleted U2OS cells.

(C) Quantification of fork restart in control- or XRCC3-depleted U2OS cells. The means and SD (bars) of at least three independent experiments are shown. Values marked with asterisks are significantly different from control (Student's t test, ∗∗p < 0.01 and ∗∗∗p < 0.001).