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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Stroke. 2010 Oct;41(10 Suppl):S139–S143. doi: 10.1161/STROKEAHA.110.596056

Table 1. Association of Extensive Leukoaraiosis with Incident Events in the Framingham Heart Study.

Data from 2,229 participants with baseline MRI, mean age 62±9 years, followed prospectively for 5-6 years on average. Extensive leukoaraiosis (n=313) was defined as white matter lesion volume, measured using quantitative methods and expressed as percent of the total intracranial volume, greater than one standard deviation above the age-adjusted mean.1

Stroke Dementia Death
HR 95% CI HR 95% CI HR 95% CI
Extensive Leukoaraiosis 2.28 1.02-5.13 3.97 1.10-14.30 2.27 1.41-3.65