Table 2.
Genetic polymorphisms in the BER pathway and lung cancer risk: OGG1 Ser326Cys polymorphism.
| Author, published year (reference no.) | Ethnicity | No. of Cases/Controls | Source of controls | OR (95% CI)* | Quality control of genotyping | ||
|---|---|---|---|---|---|---|---|
| Ser/Cys | Cys/Cys | ||||||
| Sugimura et al., 1999 [16] | Asian | 241/197 | Hospital | 0.80 (0.52–1.21) |
1.13 (0.63–2.02) |
Sequencing | |
| Wikman et al., 2000 [17] | Caucasian | 105/105 | Hospital | 0.66 (0.37–1.17) |
2.20 (0.41–11.8) |
Sequencing | |
| Ito et al., 2002 [18] | Asian | 138/240 | Hospital | 1.02 (0.63–1.67) |
0.85 (0.46–1.56) |
None | |
| Sunaga et al., 2002 [19] | Asian | 198/152 | Hospital | 1.49 (0.91–2.43) |
0.98 (0.54–1.77) |
None | |
| Le Marchand et al., 2002 [20] | Admixed population | 298/405 | Population | 0.90 (0.65–1.26) |
1.76 (1.15–2.71) |
Sequencing | |
| Lan et al., 2004 [21] | Asian | 118/109 | Population | 1.96 (1.10– 3.48) |
1.84 (0.83–4.06) |
None | |
| Park et al., 2004 [22] | Mostly composed of Caucasians | 179/350 | Screening | 1.89 (1.27–2.80) |
4.10 (1.65–10.2) |
Sequencing | |
| Vogel et al., 2004 [23] | Caucasian | 256/269 | Population | 1.09 (0.75– 1.60) |
0.78 (0.35–1.72) |
Replication (random samples) | |
| Liang et al., 2005 [24]‡ | Asian | 227/227 | Hospital | 0.94 (0.63–1.41) |
0.98 (0.33–2.87) |
Sequencing | |
| Hung et al., 2005 [25] | Mostly composed of Caucasians | 2,155/2,163 | Hospital | 0.90 (0.79–1.03) |
1.15 (0.84–1.57) |
Replication (random samples) | |
| Zienolddiny et al., 2006 [26]‡ | Caucasian | 326/386 | Population | 0.91 (0.64–1.29) |
0.63 (0.40–0.97) |
Replication (all samples) | |
| Matullo et al., 2006 [27] | Caucasian | 116/1094 | Population | 1.26 (0.83– 1.91) |
0.82 (0.21–2.33) |
Replication (random samples) | |
| Kohno et al., 2006 [28] | Asian | 1097/394 | Hospital | 1.24 (0.94–1.63) |
1.43 (1.02–2.01) |
None | |
| Sørensen et al., 2006 [29] | Caucasian | 431/796 | Population | 1.04 (0.80–1.35) |
1.18 (0.63–2.21) |
Replication (random samples) | |
| De Ruyck et al., 2007 [30] | Caucasian | 110/110 | Hospital | 0.58 (0.33–1.02) |
0.61 (0.13–2.82) |
None | |
| Karahlil et al., 2008 [31] | Turkish | 165/250 | Hospital | 0.82 (0.54–1.24) |
0.65 (0.32–1.29) |
None | |
| Miyaishi et al., 2009 [32] | Asian | 108/121 | Hospital | 1.47 (0.79–2.73) |
1.34 (0.65–2.77) |
None | |
| Chang et al., 2009 [33] | Latino | 112/296 | Population | 0.91 (0.56–1.47) |
1.05 (0.45–2.32) |
Replication (random samples) | |
| Chang et al., 2009 [33] | African-American | 254/280 | Population | 1.32 (0.89–1.98) |
0.89 (0.25–3.00) |
Replication (random samples) | |
|
| |||||||
| Summary** | No. of populations | Cochran Q test for heterogeneity | |||||
| Ser/Cys | Cys/Cys | ||||||
|
| |||||||
| All | 17 | 6,181/7,331 | 1.04 (0.94–1.23) |
1.22 (1.02–1.45) |
0.004 | 0.220 | |
| Caucasian (mostly composed of Caucasians) | 7 | 3,352/4,887 | 1.02 (0.81–1.29) |
1.24 (0.84–1.83) |
0.004 | 0.133 | |
| Asian | 6 | 1,900/1,213 | 1.23 (0.97–1.55) |
1.24 (1.00–1.55)† |
0.159 | 0.572 | |
*Crude odds ratio and 95% confidence interval.
**Based on random effects model.
† P = .052.
‡Excluded from the meta-analysis because genotype distribution of control population was not in Hardy-Weinberg equilibrium. NA, not available.