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. Author manuscript; available in PMC: 2010 Oct 21.

Published in final edited form as: J Mol Biol. 2008 Jul 16;382(2):385–401. doi: 10.1016/j.jmb.2008.07.013

Fig. 4 — Inhibition of cell migration by B6-1 and B6-2. (a-c) Charts showing that B6-1 and B6-2 blocked the migration of αvβ6-expressing cells towards LAP. VB6 cells were allowed to migrate through LAP-coated Transwell® filters. Inhibition of cell migration was observed for B6-1, B6-2 (both at 50 μg/ml) and 10D5 in (a), in a concentration-dependent manner for B6-1 in (b) and B6-1 and B6-2 (at 100 nM) and the 20-mer VP1 peptide, A20FMDV2²⁴ (at 1, 10 and 100 μM) in (c). The control antibody W6/32 (anti-major histocompatibility complex class 1) and 10D5 were used at 1:100 and 10 μg/ml, respectively. The data represent the mean of quadruplet measurements and error bars represent the standard deviation at each data point (a-c).

Fig. 4 — Inhibition of cell migration by B6-1 and B6-2. (a-c) Charts showing that B6-1 and B6-2 blocked the migration of αvβ6-expressing cells towards LAP. VB6 cells were allowed to migrate through LAP-coated Transwell® filters. Inhibition of cell migration was observed for B6-1, B6-2 (both at 50 μg/ml) and 10D5 in (a), in a concentration-dependent manner for B6-1 in (b) and B6-1 and B6-2 (at 100 nM) and the 20-mer VP1 peptide, A20FMDV2²⁴ (at 1, 10 and 100 μM) in (c). The control antibody W6/32 (anti-major histocompatibility complex class 1) and 10D5 were used at 1:100 and 10 μg/ml, respectively. The data represent the mean of quadruplet measurements and error bars represent the standard deviation at each data point (a-c).