FIG. 6.

Polyol accumulation in rat retinal pericytes cultured for 48 h with/without 10 μM of the aldose reductase inhibitors (ARIs), AL-1576, tolrestat, and zopolrestat; or the sorbitol dehydrogenase inhibitor (SDI), CP-166,572. Similar inhibitions of (A) sorbitol and (B) galactitol were observed with all three ARIs. The SDI increased sorbitol levels by inhibiting its conversion to fructose but had no effect on galactitol concentrations because galactitol is not further metabolized. Mean ± SD, n = 4. *P < 0.05 versus untreated cells; **P < 0.05 versus CP-166,572-treated cells.