Table 1.

Inclusion and Exclusion Criteria

Inclusion criteria	Exclusion criteria
≥40 years of age	Presence of any form of glaucoma other than OAG
Clinical diagnosis of OAG in at least one eye	Any concurrent infectious/noninfectious conjunctivitis, keratitis, or uveitis in either eye
At screening visit: mean diurnal IOP ≥20 mmHg under treatment with beta-blockers (at least 6 months) in monotherapy	Any abnormality preventing reliable applanation tonometry in study eye(s)
At baseline visit: mean diurnal IOP ≥20 mmHg under treatment with timolol 0.5 BID in monotherapy	Patients previously treated with argon laser trabeculoplasty and/or ocular filtering surgical intervention
Early visual-field defect	Progressive retinal or optic nerve disease due to any cause
Willingness to comply with the investigator's and protocol indications	Asthma or other obstructive pulmonary disease
Visual acuity ≥0.3 (ETDRS scalea) in both eyes	Cardiogenic shock, 2° or 3° atrioventricular block, sinus bradycardia, or heart failure
Spherical refractive error between +3.00 and −6.00 diopters	Diabetes with any sign of retinopathy (hemorrhages, hard and/or cotton wool spots, macular edema)
	Systemic medications that affect IOP or systemic blood pressure were ineligible unless the patients' medication dosages were stable ≥6 months before the screening visit
	Pregnant or nursing women

Abbreviations: OAG, open-angle glaucoma; IOP, intraocular pressure; ETDRS, Early Treatment Diabetic Retinopathy Study.

^aSee reference 27.