Table 3.
Baseline Hemodynamic Parameters in Dorzolamide/Timolol and Brinzolamide/Timolol Treatment Groups
| Number | DT 70 | BT 76 | P value |
|---|---|---|---|
| PSV OA (cm/s) | |||
| Mean (SD) | 34.1 (2.8) | 35.2 (3.0) | 0.068 |
| 95% CI | 34.2–34.8 | 34.5–35.9 | |
| EDV OA (cm/s) | |||
| Mean (SD) | 8.8 (0.9) | 9.0 (0.9) | 0.119 |
| 95% CI | 8.5–9.0 | 8.8–9.2 | |
| RI OA | |||
| Mean (SD) | 0.74 (0.05) | 0.74 (0.02) | 0.658 |
| 95% CI | 0.74–0.75 | 0.74–0.75 | |
| PSV PCA (cm/s) | |||
| Mean (SD) | 13.6 (1.0) | 13.2 (1.4) | 0.074 |
| 95% CI | 13.3–13.8 | 12.9–13.5 | |
| EDV PCA (cm/s) | |||
| Mean (SD) | 4.7 (0.5) | 4.5 (0.5) | 0.068 |
| 95% CI | 4.6–4.8 | 4.4–4.7 | |
| RI PCA | |||
| Mean (SD) | 0.66 (0.02) | 0.66 (0.03) | 0.612 |
| 95% CI | 0.65–0.66 | 0.66–0.67 | |
| PSV CRA (cm/s) | |||
| Mean (SD) | 12.2 (1.5) | 12.4 (1.6) | 0.296 |
| 95% CI | 11.8–12.5 | 12.1–12.8 | |
| EDV CRA (cm/s) | |||
| Mean (SD) | 4.1 (0.7) | 4.2 (0.7) | 0.347 |
| 95% CI | 4.0–4.3 | 4.1–4.4 | |
| RI CRA (cm/s) | |||
| Mean (SD) | 0.66 (0.03) | 0.66 (0.03) | 0.703 |
| 95% CI | 0.66–0.67 | 0.65–0.67 | |
| OPPa (mmHg) | |||
| Mean (SD) | 36.9 (4.9) | 36.6 (4.3) | 0.730 |
| 95% CI | 35.7–38.0 | 35.6–37.6 | |
| Min | 26.9 | 26.1 | |
| Max | 46.0 | 44.7 | |
Abbreviations: DT, dorzolamide/timolol; BT, brinzolamide/timolol; SD, standard deviation; 95% CI, 95% confidence interval; PSV, peak systolic velocity; EDV, end diastolic velocity; RI, resistivity index; OA, ophthalmic artery; PCA, posterior ciliary arteries; CRA, central retinal artery; OPPa, ocular perfusion pressure.
P values were calculated comparing the parameters at baseline between the two study groups (one-way ANOVA test); P values were considered statistically significant if lower than 0.05.
a
OPP = ⅔ (MAP – IOP).