Table 4.

Overview of the Values of Color Doppler Imaging Measurements, Ocular Perfusion Pressure, and Intraocular Pressure and Their Changes to Baseline for Study Treatment Groups

	Dorzolamide/timolol treatment		Brinzolamide/timolol treatment		Difference between treatment groups
Variable	Mean (95% CI) difference from timolol baseline	P value	Mean (95% CI) difference from timolol baseline	P value	Mean (95% CI)	P value
Ophthalmic artery
PSV	−0.08 (−1.01 to 0.84)	0.861	−0.01 (−0.98 to 0.98)	0.995	−1.21 (−2.73 to 0.31)	0.093
EDV	1.22 (0.90 to 1.56)	<0.001	0.02 (−0.26 to 0.30)	0.865	0.96 (0.64 to 1.27)	<0.001
RI	−0.04 (−0.05 to −0.03)	<0.001	0.00 (−0.01 to 0.01)	0.713	−0.04 (−0.05 to −0.03)	<0.001
Short posterior ciliary arteries
PSV	1.18 (0.82 to 1.53)	<0.001	0.37 (−0.09 to 0.79)	0.101	0.79 (0.36 to 1.21)	<0.001
EDV	0.53 (0.36 to 0.69)	<0.001	0.08 (−0.09 to 0.25)	0.359	0.45 (0.26 to 0.65)	<0.001
RI	−0.04 (−0.05 to −0.03)	<0.001	0.00 (−0.01 to 0.01)	0.379	−0.04 (−0.05 to −0.03)	<0.001
Central retinal artery
PSV	1.47 (0.94 to 1.99)	<0.001	0.38 (−0.14 to 0.89)	0.155	0.83 (0.28 to 1.36)	0.003
EDV	0.67 (0.43 to 0.91)	<0.001	0.10 (−0.13 to 0.34)	0.409	0.47 (0.38 to 0.55)	<0.001
RI	−0.04 (−0.05 to −0.03)	<0.001	0.00 (−0.01 to 0.01)	0.643	−0.04 (−0.05 to −0.03)	0.002
OPP	4.2 (3.5 to 4.8)	<0.001	4.1 (3.4 to 4.8)	<0.001	0.1 (−0.8 to 1.4)	0.555
IOP	−4.3 (−4.5 to −4.2)	<0.001	−4.3 (−4.4 to −4.2)	<0.001	0.0 (−0.28 to 0.30)	0.841

Abbreviations: PSV, peak systolic velocity (cm/s); EDV, end diastolic velocity (cm/s); RI, resistance index; OPP, ocular perfusion pressure (mmHg); IOP, intraocular pressure (mmHg).

P values are calculated comparing the parameters at baseline and at the end of the study (two-way ANOVA test); P values were considered statistically significant if lower than 0.005 (Bonferroni correction).