Table 5.

Overview of the Values of Color Doppler Imaging Measurements, Ocular Perfusion Pressure, and Intraocular Pressure and Their Changes to Baseline for Study Treatment Groups (per Protocol Analyses)

	Dorzolamide/timolol treatment		Brinzolamide/timolol treatment		Difference between treatment groups
Variable	Mean (95% CI) difference from timolol baseline	P value	Mean (95% CI) difference from timolol baseline	P value	Mean (95% CI)	P value
Ophthalmic artery
PSV	−0.10 (−1.31 to 1.13)	0.890	−0.09 (−1.40 to 1.20)	0.892	−0.96 (−2.25 to 0.32)	0.140
EDV	1.33 (0.97 to 1.68)	<0.001	−0.06 (−0.41 to 0.29)	0.728	1.08 (0.70 to 1.46)	<0.001
RI	−0.04 (−0.05 to −0.03)	<0.001	0.00 (−0.01 to 0.01)	0.532	−0.04 (−0.05 to −0.03)	<0.001
Short posterior ciliary arteries
PSV	1.15 (0.70 to 1.60)	<0.001	0.38 (−0.33 to 1.08)	0.292	1.29 (0.72 to 1.87)	<0.001
EDV	0.61 (0.42 to 0.81)	<0.001	−0.02 (−0.28 to 0.24)	0.896	0.61 (0.39 to 0.85)	<0.001
RI	−0.04 (−0.05 to −0.03)	<0.001	0.01 (−0.01 to 0.03)	0.097	−0.05 (−0.06 to −0.04)	<0.001
Central retinal artery
PSV	1.17 (0.55 to 1.78)	<0.001	0.11 (−0.66 to 0.87)	0.783	1.14 (0.42 to 1.85)	0.002
EDV	0.60 (0.31 to 0.90)	<0.001	−0.01 (−0.35 to 0.34)	0.968	0.48 (0.15 to 0.81)	0.005
RI	−0.04 (−0.06 to −0.02)	0.001	0.00 (−0.01 to 0.02)	0.619	−0.04 (−0.06 to −0.03)	0.008
OPP	4.2 (2.4 to 6.1)	<0.001	4.2 (2.4 to 6.0)	<0.001	0.1 (−0.8 to 1.4)	0.842
IOP	−4.4 (−4.8 to −3.9)	<0.001	−4.3 (−4.9 to −3.8)	<0.001	0.0 (−0.28 to 0.30)	0.753

Abbreviations: PSV, peak systolic velocity (cm/s); EDV, end diastolic velocity (cm/s); RI, resistance index; OPP, ocular perfusion pressure (mmHg); IOP, intraocular pressure (mmHg).

P values are calculated comparing the parameters at baseline and at the end of the study (two-way ANOVA test); P values were considered statistically significant if lower than 0.005 (Bonferroni correction).