Table 6.
Systemic and Ocular Adverse Events
| Event | DT (70) | BT (76) | P value |
|---|---|---|---|
| Hyperemia | 4 | 5 | 0.906 |
| Tearing | 12 | 8 | 0.358 |
| Foreign body sensation | 17 | 14 | 0.513 |
| Itching | 25 | 22 | 0.478 |
| Burning/stinging | 18 | 7 | 0.014 |
| Blurred vision | 5 | 20 | 0.002 |
| Punctate keratitis | 3 | 3 | 0.743 |
| Taste perversion | 15 | 18 | 0.894 |
| Flu | 8 | 11 | 0.757 |
| Headache | 7 | 5 | 0.656 |
| Back pain | 13 | 15 | 0.967 |
Abbreviations: DT, dorzolamide/timolol; BT, brinzolamide/timolol.
P values were calculated comparing the adverse events at month 60 (Fisher exact test); P values were considered statistically significant if lower than 0.05.