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. 2010 Oct 18;191(2):313–329. doi: 10.1083/jcb.201003090

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© 2010 Malureanu et al.

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Figure 8. — Cdc20 hypomorphic mice are not cancer prone despite aneuploidy. (A–C) Overall (A), skin (B), and lung (C) tumor incidence of DMBA-treated Cdc20^+/+, Cdc20^+/−, Cdc20^H/H, and Cdc20^−/H mice. Error bars represent 95% confidence intervals using the modified Wald method for proportions. There were no statistical differences between Cdc20 mutant and wild-type mice (by Fisher’s exact χ² test). (D and E) Mean (D) and median (E) number of DMBA-induced lung tumors in mice of the indicated genotypes. Error bars in D represent SEM, and error bars in E represent nonparametric two-sided 95% confidence intervals for the median. *, P = 0.0289 versus Cdc20^+/+ (by unpaired t test). (F) Kaplan–Meier overall survival curves of Cdc20^+/+ and Cdc20^−/H mice. We note that Cdc20^−/H mice remained indistinguishable from Cdc20^+/+ and developed no obvious pathologies. (G) Kaplan–Meier tumor-free survival curves of mice that are presented in F. Animals that died without tumors were censored from the data.