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Progressive reduction of Cdc20 in splenocytes leads to increasing aneuploidy
| Mitotic MEF genotype | Age | Aneuploid figures | Karyotypes w/ indicated chromosome No. | Mitotic figures w/ PMSCS | |||||
| 37 | 38 | 39 | 40 | 41 | 42 | ||||
| % | % | ||||||||
| +/+ | 5 mo (3) | 0 (0) | NA | NA | NA | 150 | NA | NA | 0 (0) |
| Cdc20+/− | 5 mo (3) | 15 (1) | 1 | 5 | 5 | 124 | 10 | 5 | 7 (1) |
| Cdc20H/H | 5 mo (3) | 17 (1) | NA | 3 | 8 | 125 | 7 | 7 | 10 (1) |
| Cdc20−/H | 5 mo (3) | 21 (1) | NA | 4 | 9 | 119 | 10 | 8 | 11 (1) |
150 mitotic figures were inspected. NA, not applicable. Numbers in parentheses indicate SD.
