Table 3.
Unadjusted and adjusted odds ratios with the corresponding 95% confidence intervals for the association of NOS3 genotypes and hypertension: comparisons for the dominant, recessive, additive, and codominant models of the mutant alleles (786C*, 4a*, 894T*).
| Polymorphism | Unadjusted | P-value | Adjusted | P-value |
|---|---|---|---|---|
| OR (95% CI) | OR (95% CI) | |||
| T786C | ||||
| Dominant model | 1.23 (0.85–1.79) | .28 | 1.30 (0.64–2.63) | .47 |
| Recessive model | 1.33 (0.83–2.15) | .24 | 0.77 (0.33–1.83) | .56 |
| Additive model | 1.46 (0.86–2.49) | .16 | 0.99 (0.38–2.62) | .98 |
| Codominant model | 1.03 (0.73–1.42) | .86 | 1.48 (0.75–2.93) | .26 |
|
| ||||
| Intron 4a/b | ||||
| Dominant model | 0.64 (0.44–0.93) | .02 | 0.52 (0.26–1.04) | .06 |
| Recessive model | 0.43 (0.14–1.36) | .15 | 0.49 (0.08–3.07) | .45 |
| Additive model | 0.38 (0.12–1.21) | .10 | 0.40 (0.06–2.78) | .35 |
| Codominant model | 0.69 (0.48–1.02) | .06 | 0.56 (0.28–1.13) | .10 |
|
| ||||
| G894T | ||||
| Dominant model | 1.05 (0.75–1.49) | .77 | 1.51 (0.78–2.92) | .22 |
| Recessive model | 1.25 (0.76–2.07) | .37 | 1.04 (0.38–2.77) | .94 |
| Additive model | 1.25 (0.74–2.14) | .41 | 1.28 (0.46–3.56) | .64 |
| Codominant model | 0.94 (0.67–1.34) | .75 | 1.51 (0.77–2.96) | .23 |