Table 3.
Pathologic Characteristics and Univariate Analysis of Prognostic Risk Factors
| No. | Cumulative patient survival* | Cumulative tumor-free survival* | ||||||
|---|---|---|---|---|---|---|---|---|
| Risk factor | Hx | Tx | Hx | Tx | p Value | Hx | Tx | p Value |
| Gender | ||||||||
| Female | 23 | 10 | 18.2 ± 3.4 | 20.2 ± 1.3 | > 0.41 | 12.0 ± 1.2 | 14.6 ± 2.0 | > 0.52 |
| Male | 21 | 10 | 16.2 ± 5.9 | 11.3 ± 4.0 | 23.4 ± 17.2 | 32.1 ± 16.7 | ||
| Age (y) | ||||||||
| ≤ 60 | 16 | 19 | 16.2 ± 5.5 | 20.2 ± 4.5 | > 0.81 | 6.8 ± 14.9 | 17.7 ± 4.1 | > 0.84 |
| > 60 | 18 | 1 | 18.3 ± 3.1 | 17.6 ± 0.0 | 12.9 ± 1.1 | 15.6 ± 0.0 | ||
| Chemo/rads | ||||||||
| Yes | 5 | 12 | 7.2 ± 5.1 | 13.2 ± 2.9 | > 0.07 | 7.2 ± 4.9 | 32.1 ± 9.1 | > 0.55 |
| No | 29 | 8 | 18.3 ± 2.9 | 20.9 ± 5.8 | 12.9 ± 3.4 | 10.5 ± 2.1 | ||
| Tumor size | ||||||||
| ≤ 5 cm | 10 | 7 | 16.2 ± 44.4 | 20.9 ± 10.0 | > 0.59 | (73.3 ± 28.3) | (18.7 ± 3.8) | > 0.57 |
| > 5 cm | 24 | 13 | 18.1 ± 5.1 | 19.2 ± 3.4 | 12.9 ± 3.4 | 15.6 ± 4.1 | ||
| Tumor | ||||||||
| Single | 19 | 7 | 77.1 ± 59.0 | 21.1 ± 10.3 | < 0.014 | 64.5 ± 18 | (68.9 ± 10.4) | < 0.03 |
| Multiple | 15 | 13 | 10.1 ± 4.7 | 19.2 ± 3.4 | 9.0 ± 4.9 | 13.1 ± 3.6 | ||
| Distribution | ||||||||
| Unilobar | 20 | 7 | 38.4 ± 16.6 | 28.5 ± 7.7 | < 0.011 | (60.2 ± 19.5) | (68.9 ± 10.4) | < 0.03 |
| Bilobar | 14 | 13 | 8.9 ± 1.8 | 17.6 ± 4.7 | 7.2 ± 1.6 | 13.1 ± 3.1 | ||
| Vascular invasion | ||||||||
| V0 | 10 | 5 | 77.1 ± 57.1 | 21.1 ± 8.6 | > 0.08 | (44.3 ± 12.4) | (29.7 ± 12.2) | < 0.02 |
| V1 + V2 | 24 | 15 | 16.2 ± 5.3 | 19.2 ± 3.6 | 11.2 ± 3.6 | 13.1 ± 2.7 | ||
| Lymph nodes | ||||||||
| Negative | 28 | 14 | 22.4 ± 11.4 | 20.2 ± 1.8 | < 0.001 | 15.9 ± 8.4 | 32.1 ± 16.6 | < 0.0001 |
| Positive | 6 | 6 | 6.5 ± 2.2 | 6.6 ± 8.6 | 4.2 ± 1.0 | 5.2 ± 4.0 | ||
| Margins | ||||||||
| Negative | 24 | 16 | 38.4 ± 28.1 | 19.2 ± 2.6 | < 0.0001 | 23.4 ± 7.9 | 17.7 ± 11.3 | < 0.0001 |
| Positive | 10 | 4 | 7.2 ± 1.8 | 0.6 ± 14.3 | 5.3 ± 1.2 | 1.5 ± 0.9 | ||
| pTNM stage | ||||||||
| I + II | 9 | 3 | 92.1 ± 0.0 | 21.1 ± 6.4 | < 0.04 | (57.9 ± 13.0) | (19.8 ± 3.5) | < 0.02 |
| III + IV | 25 | 17 | 16.2 ± 7.1 | 19.2 ± 3.8 | 11.2 ± 3.4 | 14.6 ± 3.0 | ||
Survival analysis with the Kaplan-Meier method with stratification by type of surgery (eg, resection or transplant) was performed. Each statistic was computed separately for both types of surgery, after which the values of the observed and expected numbers of deaths in each strata were combined into the final Log-Rank statistic. All p values shown were obtained by this procedure.
*
Median ± SE, in months.
Hx, hepatic resection; Tx, transplantation.