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. Author manuscript; available in PMC: 2011 Oct 19.
Published in final edited form as: Biochemistry. 2010 Oct 19;49(41):9011–9019. doi: 10.1021/bi101139q

Figure 6.

Figure 6

Native CYP3A4, CYP3A4F215Q, and CYP3A4F215G production of raloxifene metabolites. The relative amounts of metabolites were estimated with an internal standard and concentration is expressed in arbitrary units (AU). Mutations of Phe215 reduced raloxifene dehydrogenation, demonstrated by the decreased production of GS-RA, the GSH adduct of the dehydrogenated product. (*) Indicates a significant difference (p < 0.05, n = 5) compared to native CYP3A4.