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Kinetic constants for 6β-hydroxylation of testosterone by CYP3A4 and mutants
| Enzyme | Km (μM) | Vmax (nmol/min/nmol) | Vmax/Km |
|---|---|---|---|
| WT | 240 ± 20 | 21 ± 4 | 0.086 |
| S119A | 230 ± 20 | 29 ± 1 | 0.13 |
| T309V | 110 ± 20 | 4.5 ± 0.4 | 0.040 |
| F215G | 370 ± 30 | 16 ± 1 | 0.043 |
| F215Q | 320 ± 20 | 17 ± 01 | 0.053 |
