Figure 4.

Effect of different relative attribute clearance rates on patient exposure to mAb. Calculated results, over two half-lives, for a mAb with an initial concentration of 350 µg/mL, 20% attribute B at time of injection and a first order mAb clearance rate corresponding to a half-life of 30 days. (A) Proportion of mAb containing attribute B as a function of rate constant for reduction in the proportion of attribute B (k_B) and rate constant for mAb elimination (k_mAb). (B) Calculated decrease in patient exposure (partial AUC) to mAb as a result of three different first order relative elimination rates of the attribute. The black curve represents mAb elimination in the absence of faster attribute elimination. Colored curves show mAb elimination kinetics with different relative attribute elimination rates matching the respective colors in (A).