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. 2010 Sep-Oct;2(5):528–538. doi: 10.4161/mabs.2.5.12545

Table 2.

Analysis of the differences between human and macaque IGLV regions

Human Vλ gene Macaque V gene (“scaffold”) encoding the V region most similar to the region encoded by the human V gene (allele *01) Human V gene allele encoding the V region most similar to the macaque V region Nb of alleles of the human V gene encoding the V region most similar to the macaque V region Human/macaque degree of identity (V region) Human/macaque degree of identity (FRs only) Mean interallelic degree of identity (V region) Mean interallelic degree of identity (FRs only)
IGLV3-27 1099214733386:978–2238 IGLV3-27*01 1 93.0 93.6 / /
IGLV3-1 1099553000069:1282904–1284164 IGLV3-1*01 1 85.0 89.7 / /
IGLV3-19 1099553000069:1552136–1553396 IGLV3-19*01 1 95.0 96.2 / /
IGLV3-32
IGLV3-22 1099553000069:1568051–1569332 IGLV3-22*01 1 84.0 83.3 / /
IGLV5-37 1099553000069:1968429–1969716 IGLV5-37*01 1 87.0 89.7 / /
IGLV1-44 1099553000069:1985144–1986410 IGLV1-44*01 1 89.0 92.3 / /
IGLV5-52 1099553000069:2229671–2230958 IGLV5-52*01 1 92.0 91.0 / /
IGLV5-39
IGLV5-45 1099553000069:2008529–2009816 IGLV5-48*01 1 91.0 94.9 / /
IGLV5-48
IGLV1-50 1099553000069:2031556–2032822 IGLV1-50*01 1 89.0 92.3 / /
IGLV1-36 1099553000069:1890248–1891514 IGLV1-36*01 1 85.0 87.2 / /
IGLV6-57 1099553000069:2328740–2330006 IGLV6-57*01 1 89.0 91.0 / /
IGLV4-3 1099553000069:1414675–1415950 IGLV4-3*01 1 87.0 91.0 / /
IGLV11-55 1099553000069:2361853–2363140 IGLV11-55*01 1 93.0 93.6 / /
16 13 13 89.2 91.2
IGLV2-33 14164696 IGLV2-18*02 4 92.0 96.2 98.7 98.7
IGLV3-16 1099214728962:318–1578 IGLV3-25*03 3 95.0 96.2 99.0 99.0
IGLV3-25
IGLV3-10 1099553000069:1464937–1466197 IGLV3-10*01 2 94.0 93.6 98.0 99.0
IGLV2-18
IGLV2-23 1099553000069:1512475–1513744 IGLV2-8*01 2 94.0 94.9 99.0 99.0
IGLV2-8
IGLV2-11 1099553000069:1577292–1578561 IGLV2-11*01 3 94.0 96.2 100.0 100.0
IGLV2-14
IGLV3-21 1099553000069:1588271–1589531 IGLV3-21*01 3 90.0 91.0 96.5 97.5
IGLV3-12 1099553000069:1524648–1525908 IGLV3-21*01 3 90.0 91.0 96.5 97.5
IGLV3-9
IGLV1-51 1099553000069:1923387–1924653 IGLV1-51*01 2 85.0 85.9 99.0 100.0
IGLV1-40 1099553000069:1928395–1929661 IGLV1-40*01 3 89.0 91.0 97.5 97.5
IGLV1-47 1099553000069:2003910–2005176 IGLV1-47*01 2 94.0 96.2 99.0 100.0
IGLV9-49 1099553000069:2015284–2016562 IGLV9-49*03 3 94.0 93.6 100.0 100.0
IGLV7-46 1099553000069:2046219–2047488 IGLV7-46*01 2 96.0 98.7 99.0 99.0
IGLV7-43 1099553000069:1994667–1995936 IGLV7-46*01 2 94.0 93.0 99.0 99.0
IGLV4-60 1099553000069:2249750–2251025 IGLV4-69*02 2 93.0 92.3 100.0 100.0
IGLV4-69
IGLV10-54 1099553000069:2338581–2339847 IGLV10-54*01 3 99.0 98.7 97.0 97.5
IGLV8-61 1099553000069:2464913–2466182 IGLV8-61*01 3 94.0 94.9 99.0 99.0
22 16 14 92.9 94.0 98.7 99.0
38 29 27 91.2 92.7 98.7 99.0

Analysis of the differences between human and macaque IGHV regions. All human IGLV genes are shown on the left column. Macaque IGLV regions, retrieved from the M. mulatta sequenced genome by analogy with the regions encoded by human IGLV genes, and identified by their encoding DNA (scaffold), are presented in the second column. Alleles of human IGLV regions, most homologous with each macaque IGLV region, are indicated by the name of their gene in the third column. Percents of identity existing between the regions encoded by each pair of most homologous macaque and human IGHV regions are shown in columns four and five (whole V region and framework regions only, respectively). If applicable, the percents of identity existing between alleles of each human IGLV regions are shown in the last columns (whole V region and framework regions only, columns six and seven). The upper part presents IGLV genes which have no allelic polymorphism, and conversely for the lower part; both parts are separated by a bold black line. In each column, the number of sequences is presented on the last line of each part, and on the last line of the table for the whole isotype.