Table 2.
Analysis of the differences between human and macaque IGLV regions
| Human Vλ gene | Macaque V gene (“scaffold”) encoding the V region most similar to the region encoded by the human V gene (allele *01) | Human V gene allele encoding the V region most similar to the macaque V region | Nb of alleles of the human V gene encoding the V region most similar to the macaque V region | Human/macaque degree of identity (V region) | Human/macaque degree of identity (FRs only) | Mean interallelic degree of identity (V region) | Mean interallelic degree of identity (FRs only) |
| IGLV3-27 | 1099214733386:978–2238 | IGLV3-27*01 | 1 | 93.0 | 93.6 | / | / |
| IGLV3-1 | 1099553000069:1282904–1284164 | IGLV3-1*01 | 1 | 85.0 | 89.7 | / | / |
| IGLV3-19 | 1099553000069:1552136–1553396 | IGLV3-19*01 | 1 | 95.0 | 96.2 | / | / |
| IGLV3-32 | |||||||
| IGLV3-22 | 1099553000069:1568051–1569332 | IGLV3-22*01 | 1 | 84.0 | 83.3 | / | / |
| IGLV5-37 | 1099553000069:1968429–1969716 | IGLV5-37*01 | 1 | 87.0 | 89.7 | / | / |
| IGLV1-44 | 1099553000069:1985144–1986410 | IGLV1-44*01 | 1 | 89.0 | 92.3 | / | / |
| IGLV5-52 | 1099553000069:2229671–2230958 | IGLV5-52*01 | 1 | 92.0 | 91.0 | / | / |
| IGLV5-39 | |||||||
| IGLV5-45 | 1099553000069:2008529–2009816 | IGLV5-48*01 | 1 | 91.0 | 94.9 | / | / |
| IGLV5-48 | |||||||
| IGLV1-50 | 1099553000069:2031556–2032822 | IGLV1-50*01 | 1 | 89.0 | 92.3 | / | / |
| IGLV1-36 | 1099553000069:1890248–1891514 | IGLV1-36*01 | 1 | 85.0 | 87.2 | / | / |
| IGLV6-57 | 1099553000069:2328740–2330006 | IGLV6-57*01 | 1 | 89.0 | 91.0 | / | / |
| IGLV4-3 | 1099553000069:1414675–1415950 | IGLV4-3*01 | 1 | 87.0 | 91.0 | / | / |
| IGLV11-55 | 1099553000069:2361853–2363140 | IGLV11-55*01 | 1 | 93.0 | 93.6 | / | / |
| 16 | 13 | 13 | 89.2 | 91.2 | |||
| IGLV2-33 | 14164696 | IGLV2-18*02 | 4 | 92.0 | 96.2 | 98.7 | 98.7 |
| IGLV3-16 | 1099214728962:318–1578 | IGLV3-25*03 | 3 | 95.0 | 96.2 | 99.0 | 99.0 |
| IGLV3-25 | |||||||
| IGLV3-10 | 1099553000069:1464937–1466197 | IGLV3-10*01 | 2 | 94.0 | 93.6 | 98.0 | 99.0 |
| IGLV2-18 | |||||||
| IGLV2-23 | 1099553000069:1512475–1513744 | IGLV2-8*01 | 2 | 94.0 | 94.9 | 99.0 | 99.0 |
| IGLV2-8 | |||||||
| IGLV2-11 | 1099553000069:1577292–1578561 | IGLV2-11*01 | 3 | 94.0 | 96.2 | 100.0 | 100.0 |
| IGLV2-14 | |||||||
| IGLV3-21 | 1099553000069:1588271–1589531 | IGLV3-21*01 | 3 | 90.0 | 91.0 | 96.5 | 97.5 |
| IGLV3-12 | 1099553000069:1524648–1525908 | IGLV3-21*01 | 3 | 90.0 | 91.0 | 96.5 | 97.5 |
| IGLV3-9 | |||||||
| IGLV1-51 | 1099553000069:1923387–1924653 | IGLV1-51*01 | 2 | 85.0 | 85.9 | 99.0 | 100.0 |
| IGLV1-40 | 1099553000069:1928395–1929661 | IGLV1-40*01 | 3 | 89.0 | 91.0 | 97.5 | 97.5 |
| IGLV1-47 | 1099553000069:2003910–2005176 | IGLV1-47*01 | 2 | 94.0 | 96.2 | 99.0 | 100.0 |
| IGLV9-49 | 1099553000069:2015284–2016562 | IGLV9-49*03 | 3 | 94.0 | 93.6 | 100.0 | 100.0 |
| IGLV7-46 | 1099553000069:2046219–2047488 | IGLV7-46*01 | 2 | 96.0 | 98.7 | 99.0 | 99.0 |
| IGLV7-43 | 1099553000069:1994667–1995936 | IGLV7-46*01 | 2 | 94.0 | 93.0 | 99.0 | 99.0 |
| IGLV4-60 | 1099553000069:2249750–2251025 | IGLV4-69*02 | 2 | 93.0 | 92.3 | 100.0 | 100.0 |
| IGLV4-69 | |||||||
| IGLV10-54 | 1099553000069:2338581–2339847 | IGLV10-54*01 | 3 | 99.0 | 98.7 | 97.0 | 97.5 |
| IGLV8-61 | 1099553000069:2464913–2466182 | IGLV8-61*01 | 3 | 94.0 | 94.9 | 99.0 | 99.0 |
| 22 | 16 | 14 | 92.9 | 94.0 | 98.7 | 99.0 | |
| 38 | 29 | 27 | 91.2 | 92.7 | 98.7 | 99.0 |
Analysis of the differences between human and macaque IGHV regions. All human IGLV genes are shown on the left column. Macaque IGLV regions, retrieved from the M. mulatta sequenced genome by analogy with the regions encoded by human IGLV genes, and identified by their encoding DNA (scaffold), are presented in the second column. Alleles of human IGLV regions, most homologous with each macaque IGLV region, are indicated by the name of their gene in the third column. Percents of identity existing between the regions encoded by each pair of most homologous macaque and human IGHV regions are shown in columns four and five (whole V region and framework regions only, respectively). If applicable, the percents of identity existing between alleles of each human IGLV regions are shown in the last columns (whole V region and framework regions only, columns six and seven). The upper part presents IGLV genes which have no allelic polymorphism, and conversely for the lower part; both parts are separated by a bold black line. In each column, the number of sequences is presented on the last line of each part, and on the last line of the table for the whole isotype.