Figure 3.

Simulations illustrating effect of varying k_in and k_out in the general antibody-ligand PK/PD model. All parameters except k_in and k_out were held constant throughout simulations and the ratio of k_in to k_out was held constant at 0.061. k_in was 0.42, 0.042 and 0.0042 nM h⁻¹ for the three scenarios. Effect of varying k_in and k_out on total antibody concentration (A–C), total ligand concentration (D–F) and free ligand concentration (G–I) are shown. (J–L) show total antibody, total ligand and free ligand concentrations on the same plot for each scenario at a 100 mg/kg dose of antibody.