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. 2010 Jul-Sep;4(3):348–352. doi: 10.4161/cam.4.3.11407

Figure 2.

Figure 2

Transcriptional activation and repression by CUX1. p110 and p75 CUX1 can activate or repress transcription depending on promoter context. These opposite regulatory effects can be best explained if we envision that CUX1 interacts with different partners on each class of genes. (A) CUX1 cooperates with yet to be identified transcriptional activators to activate expression of the Snail and Slug genes. (B) CUX1 cooperates with Snail and Slug to repress transcription of the E-Cadherin gene.