Table 1.
Definitions
Epithelial Cell | Cell with apical-basal polarity, intercellular adhesion complexes, polarized actin cytoskeleton and an underlying basal membrane |
Squamous epithelium | Layer of flat epithelial cells with irregular boundaries |
Columnar epithelium | Layer of tall epithelial cells with polygonal boundaries |
Mesenchymal cell | Cell devoid of apical-basal polarity and adhesion complexes that exhibit elongate morphology, filopodia, front end-back end polarity and invasive motility |
EMT | Epithelial to mesenchymal transition. Cells lose epithelial morphology and molecular identity and adopt mesenchymal properties |
MET | Mesenchymal to epithelial transition. Cells downregulate mesenchymal markers and upregulate epithelial factors and they assume an epithelial morphology |
Ingression | Epithelial cells undergo EMT and concomitantly leave an epithelial sheet of cells |
Egression | Mesenchymal cells join a pre-established epithelial sheet and concomitantly undergo MET |
Delamination | Cells leave an epithelium either via EMT or not |
Relamination | Cells form/join an epithelium either via MET or not |