Table 1.
Mortality risk factors in septic shock patients: monovariate analysis COPD: chronic obstructive pulmonary disease, SAPS: simplify acute physiology score, SOFA: sepsis-related organ failure assessment score, ICU: intensive care unit, RRT: renal replacement therapy, prothrombin ratio (PR).
| Survivors 146 (45.6) | Deceased174 (54.4) | P | |
|---|---|---|---|
| Comorbidities n(%) | |||
| Chronic cardiac failure | 21(14.4) | 36(21) | .1233 |
| Diabete mellitus | 29(19.9) | 40(23.4) | .4479 |
| COPD | 35(23.9) | 45(26.3) | .6321 |
| Chronic liver failure | 11(7.5) | 24(14) | .0656 |
| Chronic alcoolism | 28(19.1) | 57(33.3) | .0046 |
| Chronic renal failure | 6(4.1) | 10(5.8) | .4810 |
| Non hematologic malignancy | 16(10.9) | 20(11.6) | .8367 |
| Hematologic malignancy | 16(10.9) | 16(9.3) | .6369 |
| Immunosuppression | 25(17.1) | 24(14) | .4484 |
| Clinical presentation | |||
| Male sex n(%) | 92(63) | 111(63.8) | .8853 |
| Age (years) (mean ± SD) | 61.6 ± 15.5 | 68.5 ± 14.3 | <.0001 |
| Lactate (meq/l) (mean ± SD) | 3 ± 2.2 | 4.9 ± 4 | <.0001 |
| Platelet count (1000/mm³) (mean ± SD) | 203 ± 144 | 198 ± 143 | .7813 |
| Creatinine (mg/l) (mean ± SD) | 21.6 ± 15.4 | 22.7 ± 12.3 | .4825 |
| Bilirubine (mg/l) (mean ± SD) | 14.2 ± 13.5 | 20.6 ± 27.4 | .0157 |
| PR (%) (mean ± SD) | 58.6 ± 19.8 | 49.6 ± 20.5 | <.0001 |
| pH (mean ± SD) | 7.3 ± 0.1 | 7.2 ± 0.1 | .0007 |
| PaO2/FiO2 (mean ± SD) | 190 ± 103 | 154 ± 101 | .0021 |
| SAPS II (mean ± SD) | 52.7 ± 13.9 | 70.3 ± 20.9 | <.0001 |
| SOFA score (mean ± SD) | 10.6 ± 3 | 11.9 ± 3.1 | .0002 |
| Respiratory failure n(%) | 123(84.2) | 153(88.4) | .2746 |
| Renal failure n(%) | 30(20.5) | 53(31.1) | .0323 |
| Coagulation failure n(%) | 21(14.3) | 29(17.2) | .4869 |
| Hepatic failure n(%) | 1(0.7) | 10(6) | .0108 |
| Neurologic failure n(%) | 40(28.5) | 70(41.6) | .0169 |
| Management | |||
| Time from shock to ICU admission (hours) (mean ± SD) | 2.5 ± 5.6 | 2.2 ± 4 | .6034 |
| Adapted antibiotic therapy n(%) (mean ± SD) | 138(97.8) | 154(96.8) | .7269 |
| Time from sepsis to adapted antibiotic therapy (hours) (mean ± SD) | 8 ± 18.2 | 11.2 ± 19 | .1426 |
| Adequate antibiotic therapy n(%) | 89(92.7) | 76(83.5) | .0512 |
| Time from sepsis to adequate antibiotic therapy (hours) (mean ± SD) | 10.3 ± 23.3 | 15.4 ± 25.7 | .1698 |
| Mechanical ventilation n(%) | 116(79.4) | 166(95.9) | <.0001 |
| Noninvasive ventilation n(%) | 12(8.6) | 27(15.6) | .0614 |
| Time from shock to intubation (hours) (mean ± SD) | 2.5 ± 6.4 | 3.3 ± 9.8 | .4050 |
| RRT n(%) | 41(28) | 57(33.1) | .3304 |
| Time from shock to RRT (hours) (mean ± SD) | 29 ± 38.7 | 29.7 ± 33.4 | .9216 |
| Cristalloid volume expansion at 6 hours of sepsis (mL) (mean ± SD) | 1302 ± 1123 | 974 ± 1127 | .0135 |
| Cristalloid volume expansion at 24 hours of sepsis (mL) (mean ± SD) | 2629 ± 1748 | 1842 ± 1618 | <.0001 |
| Hydrocortisone n(%) | 123(84.2) | 147(84.4) | .9538 |
| Time from shock to initiation of hydrocortisone (hours) (mean ± SD) | 8.2 ± 13 | 7.4 ± 10.9 | .5985 |
| Activated proteine C n(%) | 13(8.9) | 8(4.6) | .1246 |
| Intensive insulin therapy n(%) | 94(64.3) | 86(49.4) | .0072 |
| Enteral nutrition n(%) | 101(70.6) | 67(51.1) | .0009 |
| Parenteral nutrition n(%) | 39(27.2) | 29(22.1) | .3256 |
| Time from shock to initiation of nutrition (days) (mean ± SD) | 2.5 ± 1.3 | 2.4 ± 1.1 | .7918 |