Figure 7.

Effects of local perfusion of F15599 in the medial prefrontal cortex on extracellular dopamine levels and antagonism by (±)WAY100635. Data are expressed as a percentage of the mean absolute amount of dopamine in the four samples collected before treatment. Top panel: the effects of different concentrations of F15599 administered through the dialysis probe from time 0 (bar), the arrow indicates saline administration (s.c.). Middle and bottom panels: the antagonist effects of (±)WAY100635 100 and 300 µM, administered through the dialysis probe, on the increase in extracellular dopamine induced by 300 µM F15599. The bar indicates the presence of compounds in the perfusion medium, the arrow indicates the addition of F15599 to the perfusion medium. Results are mean ± SEM of three to eight animals per group.