Figure 4.

Lung function parameters are impaired in LPS and TS exposed rats. Sprague-Dawley rats were exposed to tobacco smoke or air for 30 min twice a day for 2 days. On the morning of day 3 rats were exposed to saline of LPS (0.3 mg·mL⁻¹) for 30 min followed by tobacco smoke or air 5 h later. Twenty-four hours after LPS exposure (A) total lung capacity (TLC) (B) chord compliance (Cchord) and (C) FEV₁₀₀ were assessed by forced manoeuvres. Data are expressed as mean and SEM of n= 8 animals per group. (*P < 0.05 compared with air/saline exposed animals). LPS, lipopolysaccharide; TS, tobacco smoke.