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. 2010 Aug;160(8):2028–2044. doi: 10.1111/j.1476-5381.2010.00859.x

Figure 3.

Figure 3

Concentration dependent effect of NS5806 on KV4.3, KChIP2 and DPP6 in Xenopus laevis oocytes. KV4.3, KChIP2 and/or DPP6 were expressed in Xenopus laevis oocytes. Currents were repeatedly activated from −80 mV by steps to +40 mV. (A) Representative recordings of KV4.3, KV4.3/KChIP2 and KV4.3/KChIP2/DPP6 currents in presence of 0 (black), 1 (blue), 3 (red) 10 (green) or 30 (orange) µM NS5806. (B) Single exponential functions were fitted to the first 150 ms of KV4.3, KV4.3/KChIP2 and KV4.3/KChIP2/DDP6 current decays and the time constants (τ) are plotted as a function of NS5806 concentration (n= 6–8). *P < 0.05, significantly different in the absence and presence of NS5806. (C) KV4.3/KChIP2 time-course experiment. The black trace shows the effect of increasing concentrations of NS5806 on KV4.3/KChIP2 peak current decay (τ; lefthand Y axis) and the grey trace shows the effect on the peak current amplitude (I, righthand Y axis), representative of n= 6. DPP, dipeptidyl-peptidase; KChIP2, K channel interacting protein 2.