Skip to main content
. 2010 Aug;160(8):2028–2044. doi: 10.1111/j.1476-5381.2010.00859.x

Figure 4.

Figure 4

Effect of NS5806 on KV4 channels in presence or absence of KChIP2. KV4 channels were expressed with and without KChIP2 in Xenopus laevis oocytes and currents were elicited from a holding potential of −100 mV by a step to +40 mV in absence and presence of 10 µM NS5806. The first 150 ms of current decay was fitted to a mono-exponential function, and the time constants (τ) are shown as a function of voltage. (A) Representative KV4.1 (n= 5) and KV4.1/KChIP2 currents (n= 6) and τ-values as a function of voltage before and after application of drug. (B) Representative KV4.2 (n= 6) and KV4.2/KChIP2 (n= 10) currents and τ-values as a function of voltage. (C) Representative KV4.3 (n= 8) and KV4.3/KChIP2 (n= 8) currents and τ-values as a function of voltage. *P < 0.05, **P < 0.01, ***P < 0.001; significantly different in the absence and presence of NS5806. KChIP2, K channel interacting protein 2.