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Polyplex stability in 90% rabbit serum at 37°C for p(TETA/CBA)5k, poly(TETA/CBA)5kg-PEG2k, 10/90 (10% PEG) and 50/50 (50% PEG) wt/wt % formulations for p(TETA/CBA)5k-g-PEG2k and p(TETA/CBA)5k, respectively. 500ng pCMVLuc was complexed with each formulation N/P 50 (w/w 24). The relative percent of intact pDNA over time was determined by band pixel intensity using GelDoc software. Increasing the PEG wt% in the polyplex formulations inversely correlates with pDNA protection (n=2).
