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. 2010 Aug 26;26(21):2737–2743. doi: 10.1093/bioinformatics/btq474

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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1. — Proteins of disease genes and immune-related genes have higher node degree in general PPI networks than do proteins of randomly sampled genes. The average node-degree of disease genes (represented by morbid Omim genes) and immune-related genes (represented by genes upregulated at least 3-fold in expression at various time points after HMPV infection) is observed in the HsapiensPPI (top panel) and the AllspeciesPPI (bottom panel) networks to be generally higher than randomly sampled genes from the genome. In the top and lower panels, hmpv6, hmpv12, etc. refer to gene sets upregulated in expression after 6 and 12 h of HMPV infection. In brackets are the P-value estimates of higher node degree (compared with random) of disease and immune-related genes in the general PPI networks.