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. 2010 Sep 22;24(11):2207–2217. doi: 10.1210/me.2010-0179

Figure 5.

Figure 5

Ingenuity pathway analysis shows the most significant three gene networks of T+E2-treated LPs. A, IL-1β network: 29 genes were mapped principally to a network with IL-1β as a central node. B, ERK network: 22 genes were mapped to a network with ERK as a distinct node. C, TNFα network: 24 genes were mapped to a network with TNFα as a prominent node. Blue circles represent “estrogen-responsive” genes in which hormone-inducible changes were negated by antiestrogen ICI but not reversed by PRL blockade with Br. For more details of the IPA network legend, see Supplemental Fig. 1. The intensity of the node color indicates the degree of up- or down-regulation. Genes in uncolored nodes were not identified as differentially expressed in our array experiments and were incorporated into individual networks on the basis of the IPA knowledge database, indicating a relevance to this network. D, Venn diagram shows a partial overlap among the three identified gene networks.