. Author manuscript; available in PMC: 2010 Oct 21.

Published in final edited form as: J Biol Chem. 2007 Dec 18;283(8):5069–5080. doi: 10.1074/jbc.M708734200

TABLE 2.

The values of dissociation constants (K_d, µM) and Hill coefficients (n, if applicable) for the four azole antifungal inhibitors and the three structurally-characterized Mtb CYP enzymes.

	CYP130	CYP121	CYP51
Econazole	1.93 ± 0.03; n=1.37 ± 0.02	<0.2^a	0.77 ± 0.04
Miconazole	1.70 ± 0.21	<0.2^a	0.59 ± 0.03
Clotrimazole	13.3 ± 0.6; n=1.95 ± 0.05	<0.2^a	<1.0
Ketoconazole	48.0 ± 1.5	3.3 ± 0.3^b	19.0 ± 1.9

From Ref. (17).

From Ref. (48).