Skip to main content
. 2010 Oct 21;5(10):e13552. doi: 10.1371/journal.pone.0013552

Figure 4. CYCLIN E expression and Relapse Cumulative Incidence.

Figure 4

(A) Relapse Cumulative Incidence comparison between patients with CYCLIN E expression levels <1.228 (n = 84, blue line) and patients with CYCLIN E levels >1.228 (n = 28, red line). Patients with elevated CYCLIN E levels have a higher probability to relapse (CYCLIN E threshold 1.228, log rank test after Bonferroni corrections p = 0.000075). (B) RPMA results validation with Western Blot. Patients 21–24 showed high levels of CYCLIN E after RPMA analysis: 1.974, 1.896, 1.537, 1.506 respectively. Patients 25–28 showed low levels of CYCLIN E after RPMA analysis: 0.463, 0.470, 0.298, 0.292 respectively. RS4;11 cell lysate was used as positive control for antibody staining. (C) Early relapsed patients (relapsed within 910 days from diagnosis) show higher levels of CYCLIN E expression with respect to late relapsed patients (Wilcoxon test p = 0.002).