Table 2.
mRNA targets and functions of miR-124 in neuronal development and function
| Functions | Species | Targets | References |
|---|---|---|---|
| Inhibits long-term facilitation at the sensory-motor synapses | Aplysia | CREB | [45] |
| Suppresses dendritic branching by overexpression | D. melanogaster | ? | [68] |
| Promotes neuronal differentiation in spinal cord | Chick | SCP1 | [49] |
| Promotes neurite growth | P19 cells | RhoA | [71] |
| Involved in BAF53b-induced activity-dependent dendritic growth | Rodent | BAF53b | [73] |
| Promotes neuronal differentiation in developing brain | Rodent | REST, PTBP1, Ephrin-B1 | [62-64] |
| Promotes adult neurogenesis | Rodent | Sox9 | [65] |
| Promotes neuronal differentiation | Rodent | ? | [58] |
| Cocaine-induced plasticity in the adult brain | Rodent | CREB, BDNF | [85] |
BDNF, brain-derived neurotrophic factor; CREB, cAMP response element binding protein; PTBP1, polypyrimidine tract-binding protein 1; REST, RE1 silencing transcription factor; SCP1, small C-terminal domain phosphatase 1.