Table 3.
Genotype distribution for the 5 LXRβ; SNPs in obese and non obese individuals from the MONICA study and ORs [95% CI] of obesity.
Genotype | Non obese (n = 1945) | Obese (n = 373) | Crude p | Adjusted OR | [95% CI] | Adjusted p | |||
---|---|---|---|---|---|---|---|---|---|
n | Frequency | n | Frequency | ||||||
rs17373080 | CC | 937 | 0.48 | 157 | 0.43 | ||||
CG | 804 | 0.42 | 166 | 0.45 | 0.13 | 1.26 | [1.00-1.59] | 0.05 | |
GG | 191 | 0.10 | 43 | 0.12 | |||||
Total | 1932 | 366 | |||||||
rs56151148 | CC | 1595 | 0.83 | 314 | 0.85 | ||||
CT | 325 | 0.17 | 53 | 0.14 | 0.46a | 0.78 | [0.57-1.08] | 0.13 | |
TT | 11 | 0.01 | 1 | 0.00 | |||||
Total | 1931 | 368 | |||||||
rs2695121 | CC | 616 | 0.32 | 128 | 0.35 | ||||
CT | 947 | 0.49 | 182 | 0.49 | 0.30 | 0.90 | [0.71-1.14] | 0.39 | |
TT | 370 | 0.19 | 59 | 0.16 | |||||
Total | 1933 | 369 | |||||||
rs2303044 | CC | 1658 | 0.85 | 308 | 0.83 | ||||
CT | 262 | 0.14 | 60 | 0.16 | 0.41a | 1.23 | [0.91-1.67] | 0.18 | |
TT | 20 | 0.01 | 3 | 0.01 | |||||
Total | 1940 | 371 | |||||||
rs3219281 | CC | 1571 | 0.83 | 305 | 0.82 | ||||
CT | 310 | 0.16 | 61 | 0.16 | 0.77a | 1.03 | [0.76-1.39] | 0.85 | |
TT | 19 | 0.01 | 5 | 0.01 | |||||
Total | 1900 | 371 |
aFisher exact test. ORs and p values were adjusted for age, gender, centre, smoking habit, alcohol consumption and physical activity level. A dominant model was used to calculate the odds ratios. Significant p values are indicated in bold.