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View full-text article in PMC

. 2010 Oct 8;8:92. doi: 10.1186/1479-5876-8-92

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Copyright ©2010 Lavelle et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comparison of the effects of S110 and decitabine on DNA methylation of the γ-globin gene promoter region in cultured human erythroid progenitor cells. The effects of decitabine and S110 on the DNA methylation of 5 CpG sites located within the 5' γ-globin promoter region are shown. Red rectangles = methylated CpG; green rectangles = unmethylated CpG. Results are expressed as the % deoxymethylcytosine (dmC) of cytosines located within CpG dinucleotides at positions -54, -51, +5, +16, and +48 with respect to the transcriptional start site of the human γ-globin gene promoter. Each row corresponds to the sequence analysis of an individual cloned PCR product derived from bisulfite-treated DNA. Results for each CpG site (-54, -51, +5, +16, +48) are in each corresponding column.