Table 2.
Parameter | Units | Decitabine Injection (0.5 mg/kg) |
S110 injection (1.0 mg/kg) | |
---|---|---|---|---|
Compound | Decitabine | S110 | Decitabine | |
HL_LAMBDA_z | min | 93 | 39 | 58 |
Tmax | min | 30 | 16 | 15 |
Cmax | ng/ml | 16 | 6 | 17 |
AUCall | min*ng/ml | 1149 | 397 | 494 |
AUCINF_OBS | min*ng/ml | 1463 | 516 | 593 |
Pharmacokinetic data calculated for baboons treated with decitabine and S110.
HLLambda z- half life, Tmax- time of maximal drug concentration, Cmax-concentration at Tmax, AUCall-area under the curve from time of dosing to last observation, AUCINF_OBS-area under the curve from time of dosing to infinity.