Table 1.
Age adjusted association of metabolic syndrome and other related biomarkers in menopausal transition (mean ± SD)
| Variables | Pre-menopausal (n = 303) | Menopausal (n = 233) | Post-menopausal (n = 987) | P value* |
|---|---|---|---|---|
| Age (years) |
47.2 ± 2.1 |
51.5 ± 5.8 |
61.6 ± 8.5 |
< 0.001 |
| Systolic blood pressure (mmHg) |
120.2 ± 20.2 |
125.2 ± 23 |
132.4 ± 22.1 |
0.030 |
| Diastolic blood pressure (mmHg) |
77.8 ± 11.8 |
80.3 ± 12.8 |
82.5 ± 11.8 |
0.008 |
| Fasting plasma glucose (mg/dl) |
88.7 ± 29.7 |
91.2 ± 34 |
95.1 ± 38.2 |
0.393§ |
| 2 h-post-prandial glucose (mg/dl) |
115 ± 53.4 |
121 ± 67.4 |
127.3 ± 70.2 |
0.011§ |
| Total Cholesterol (mg/dl) |
209.8 ± 44.6 |
233.6 ± 54.6 |
233.3 ± 50.6 |
< 0.001† |
| LDL-C (mg/dl) |
127.2 ± 38.2 |
142.8 ± 47.3 |
142.5 ± 43.5 |
0.004† |
| Triglycerides (mg/dl) |
176.1 ± 98.9 |
213.7 ± 118.1 |
207.8 ± 104.9 |
< 0.001† |
| HDL-C (mg/dl) |
48.3 ± 10.1 |
50.4 ± 11 |
49.5 ± 10.8 |
0.121 |
| Waist (cm) |
97.6 ± 12.5 |
97.2 ± 13.4 |
98.5 ± 12.3 |
0.197 |
| Waist to hip ratio |
0.92 ± 0.07 |
0.93 ± 0.08 |
0.95 ± 0.07 |
0.391 |
| Body mass index |
28.6 ± 4.7 |
28.3 ± 5.1 |
27.6 ± 4.5 |
0.932 |
| Anti diabetes medication |
12(4%) |
13(5.6%) |
115(11.7%) |
0.003 |
| Anti hypertension medication |
35(11.6%) |
48(20.6%) |
324(32.9%) |
0.153 |
| Global Dietary Index |
0.90 ± 0.23 |
0.87 ± 0.23 |
0.84 ± 0.27 |
0.630 |
| Leisure Time Physical Activity | 62.40 ± 82.37 | 66.19 ± 88.04 | 62.09 ± 82.54 | 0.482 |
* Age adjusted P-value § Adjusted for Anti diabetes medication in addition to age
†Post hoc test did not find significant relationship between early menopausal and Post- Menopausal group