Table 1.
Polycomb genes expression in normal brain and specific tumor histologies.
| PRC | GENE | Category 1 (up-regulated) |
Category 2 (down- regulated) |
P value |
|---|---|---|---|---|
| 1 | BMI1 | Normal Brain | Glioblastoma | 5.85 E-27 |
| CBX2 | Neural Stem Cell | Glioblastoma | 4.4 E-13 | |
| CBX7 | Normal Brain | Glioblastoma | 2.2 E-27 | |
| Ganglioneur-oma/-oblastoma | Neuroblastoma | 2.4 E-7 | ||
| PCGF1 | Glioblastoma | Astrocytoma | 1.2 E-6 | |
| PCGF6 | Astrocytoma/Oligodendroglioma | Glioblastoma | 4.0 E-6 | |
| PHC2 | Astrocytoma/Glioblastoma | Oligodendroglioma | 1.4 E-7 | |
| YY1 | Anaplastic Oligoastrocytoma | Normal Brain | 1.23 E-5 | |
| Medulloblastoma with Advanced Neural Differentiation | Other hystologies | 8.86 E-27 | ||
| Oligodendroglioma | Mixed Glioma | 3.83 E-6 | ||
| 2, 3, 4 | EZH2 | Anaplastic Oligodendroglioma | Normal Brain | 1,12E-12 |
| Anaplastic Astrocytoma | Normal Brain | 3,50E-13 | ||
| Glioblastoma | Normal Brain | 2,56E-23 | ||
| Neuroblastoma | Ganglioneur-oma/-oblastoma | 4,94E-08 | ||
| Glioblastoma | Astrocytoma/Ogligodendroglioma | 1.64 E-5 | ||
| RBBP7 | Anaplastic Astrocytoma | Normal Brain | 6,0E-06 | |
| Anaplastic Oligodenroglioma | Normal Brain | 5,60E-08 | ||
| SUZ 12 | Anaplastic Oligodendroglioma | Normal Brain | 1.19 E-7 | |
| Atypical Theratoid/Rhabdoid Tumor | Medulloblastoma | 5.50 E-8 | ||
| 4 | SIRT1 | Neural Stem Cell | Glioblastoma | 9.4 E-13 |
| Oligodendroglioma | Glioblastoma Astrocytoma | 1.9 E-11 | ||
Data derived from Oncomine database. Grading analyses were performed on 35 adult and 19 pediatric brain tumors. Survival analysis was performed on a total of 97 glioblastoma patients.