Table 2.
Association between SLC6A2 genotypes and response to MPH treatment according to the CGI-I
| Response to MPH by CGI-I N (% within SLC6A2 genotype) |
|||||
|---|---|---|---|---|---|
| SLC6A2 genotype | Poor (CGI-I: 3-7) |
Good (CGI-I: 1 or 2) |
Total (% within total number) |
p-value | |
| -3081(A/T) polymorphism | A/A | 18 (62.1%) | 11 (37.9%) | 29 (25.9%) | 0.08 |
| A/T | 24 (40.0%) | 36 (60.0%) | 60 (53.6%) | ||
| T/T | 8 (34.8%) | 15 (65.2%) | 23 (20.5%) | ||
| A/A | 18 (62.1%) | 11 (37.9%) | 29 (25.9%) | 0.03 | |
| A/T+T/T | 32 (38.6%) | 51 (61.4%) | 83 (74.1%) | ||
| Total | 50 (44.6%) | 62 (55.4%) | 112 | ||
| G1287A polymorphism | G/G | 22 (37.9%) | 36 (62.1%) | 58 (51.8%) | 0.12 |
| G/A | 24 (57.9%) | 18 (42.9%) | 42 (37.5%) | ||
| A/A | 4 (33.3%) | 8 (66.7%) | 12 (10.7%) | ||
| G/G | 22 (37.9%) | 36 (62.1%) | 58 (51.8%) | 0.14 | |
| G/A+A/A | 28 (51.9%) | 26 (48.1%) | 54 (48.2%) | ||
| Total | 50 (44.6%) | 62 (55.4%) | 112 | ||