Table 3.
Plasma concentrations of artesunate and dihydroartemisinin on day-0 (pre-treatment) and at 1 and 6 hours after treatment in patients with sensitive response and recrudescence.
| Drug/Day of treatment | Sensitive response | Recrudescence response | ||
|---|---|---|---|---|
| N | Mean (95%CI)* or Median (95% CI)** | N | Mean (95%CI)* or Median (95% CI)** | |
| Artesunate: | ||||
| Day 0** | 90 | 0 | 35 | 0 |
| Hour 1* | 65 | 344 (312-375) | 30 | 323 (282-364) |
| Hour 6** | 64 | 1 (0-1,253) | 30 | 0 (0-12) |
| Dihydroartemisinin: | ||||
| Day 0** | 90 | 0 (0-10) | 35 | 0 |
| Hour 1* | 65 | 525 (452-599) | 30 | 456 (215-875)a |
| Hour 6** | 64 | 98 (13-220) | 30 | 100 (0-220) |
a = Statistically significantly lower than patients with sensitive response (student t-test; p < 0.001)