Table 1.
Peptide | Amino acid sequence | Kinetic constants by two state reaction model | ||
---|---|---|---|---|
KD (M) | ka1 (1/Ms) ka2 (1/s) |
kd(1/s) | ||
sVpr21-40 | ELLEELKSEAVRHFP35 RIWLH | 2.01 × 10-4 | ka1 = 466 ka2 = 0.0084 |
kd1 = 0.164 kd2 = 0.011 |
sVpr25-40 | ELKSEAVRHFP35 RIWLH | 4.04 × 10-4 | ka1 = 2004 Ka2 = 0.0028 |
kd1 = 0.9415 kd2 = 0.0173 |
sVpr1-40 | MEQAP5EDQGP10QREP14YNEWTTLELLEELKSEAVRHFP35 RIWLH | 2.84 × 10-4 | ka1 = 752 ka2 = 0.0073 |
kd1 = 0.37 kd2 = 0.0099 |
sVpr1-40 P5,10,14 N | MEQAN5EDQGN10QREN14YNEWT TLELLEELKSEAVRHFP35 RIWLH |
0.00615* | ka1 = 46* ka2 = 0.0047 |
kd1 = 0.56* kd2 = 0.0048 |
sVpr30-40 | AVRHFP35 RIWLH | 1.67 × 10-4 | ka1 = 2467 ka2 = 0.00145 |
kd1 = 0.527 kd2 = 0.0053 |
sVpr32-38 | RHFP35 RIW | 4.87 × 10-4 | ka1 = 924 ka2 = 0.0011 |
kd1 = 0.67 kd2 = 0.0023 |
sVpr33-37 | HFP35RI | 0.00357 | ka1 = 120.4 ka2 = 0.00138 |
kd1 = 0.66 kd2 = 0.0025 |
*ka1 beyond the values measurable by the Biacore instrument.