Fig. 1.

Epidermal defects in mice overexpressing Ets1 in the suprabasal layers of epidermis. (A) Expression of the HA-Ets1 transgene in the skin of BT mice. Arrow indicates transgene expression in the inner root sheath of the hair follicle. (B) BT newborn mice are smaller, with an eyes-open-at-birth phenotype (arrow) and have a shiny, translucent skin. (C,D) Hematoxylin and eosin staining to identify epidermal alterations in E18.5 (C) and newborn (NB) (D) BT mice as compared with the wild-type. The BT epidermis is hyperplastic, has a reduced granular layer (white brackets) and is characterized by parakeratosis (arrows) and a compact stratum corneum. Arrowhead in C indicates the presence of a superficial dermal capillary.