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Epidermal permeability barrier deficiency in mice overexpressing Ets1. (A) Dye exclusion assay on E16.5, E18.5 and newborn (NB) mice. (B) Morphology of newborn wild-type (top) and BT (bottom) cornified envelopes; inset shows higher magnification of the boxed regions. The wild-type demonstrates intact, polygonal cornified envelopes, whereas the BT shows two intact and three fragmented cornified envelopes.
