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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Inflamm Bowel Dis. 2010 Nov;16(11):1859–1870. doi: 10.1002/ibd.21288

FIGURE 1.

FIGURE 1

Reduced survival and more severe colitis in DSS-treated Eng+/− compared to Eng+/+ mice. All mice drank water containing 3% DSS for 5 days (as indicated by the bar) and then normal water; they were monitored daily for weight changes and clinical signs for up to 26 days. A) Survival of the DSS-treated Eng+/− mice was lower than for the DSS-treated Eng+/+ mice. Kaplan-Meier plots and log-rank tests were used. The DSS-treated groups (N = 46) had reduced survival compared to the respective untreated groups (N = 10). †P < 0.05 vs. corresponding control untreated group; *P < 0.05 vs. DSS-treated Eng+/+ mice. B) Greater weight loss in DSS-treated Eng+/− mice than in DSS-treated Eng+/+ mice (*P < 0.05); both DSS-treated groups lost weight starting at day 5 compared to control groups (†P < 0.05). C) Fecal blood was first noted in the DSS-treated mice at day 2, was maximal at day 7 and remained higher in the Eng+/− group (*P < 0.05) throughout the whole experiment. D) Diarrhea was first observed at day 4, maximal at day 7 and remained higher in the Eng+/− vs. Eng+/+ group (*P < 0.05).