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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Inflamm Bowel Dis. 2010 Nov;16(11):1859–1870. doi: 10.1002/ibd.21288

FIGURE 5.

FIGURE 5

Colitis, inflammation and angiogenesis scores are higher in DSS-treated Eng+/− than Eng+/+ mice. Tissue sections were scored to quantify the extent of inflammation and angiogenesis. A) Total colitis histological score was calculated from the sum of the inflammation, lack of regeneration, and crypt damage scores on hematoxilin and eosin stained sections as described in Methods. B) Inflammation score was based on leukocyte infiltration and percent gut involvement on the same sections. C) The total number of vascular protrusions (containing one to several vessels) arising from the submucosa and penetrating through the lamina muscularis and into the serosa was counted for the whole distal colon on Movat pentachrome stained sections. †P < 0.05 vs. corresponding control untreated group (at day 0); *P < 0.05 vs. DSS-treated Eng+/+ mice; N = 6 for the DSS-treated groups at all time points; N = 5 for the control groups. Data were analyzed using the non-parametric Wilcoxon rank test.