Table 2.
Comparison of Specular Microscopy Ancillary Study (SMAS) Participants with Nonparticipants
| Baseline Recipient Characteristic | Cornea Donor Study Subjects in the SMAS without Graft Failure |
Cornea Donor Study Subjects in the SMAS with Graft Failure (N = 55) | Cornea Donor Study Subjects Not in the SMAS (N = 494) | |
|---|---|---|---|---|
| 5-Year Endothelial Cell Density (N = 347) | No 5-Year Endothelial Cell Density (N = 194) | |||
| Age | ||||
| Mean (standard deviation) | 69 (8) | 71 (8) | 73 (8) | 70 (9) |
| Median (interquartile range) | 71 (64–75) | 73 (66–76) | 75 (69–79) | 72 (65–77) |
| Gender (female) | 224 (65) | 117 (60) | 36 (65) | 320 (65) |
| Race | ||||
| Caucasian | 333 (96) | 178 (92) | 50 (91) | 450 (91) |
| African American | 9 (3) | 11 (6) | 5 (9) | 25 (5) |
| Hispanic | 2 (<1) | 2 (1) | 0 | 9 (2) |
| Asian | 1 (<1) | 1 (<1) | 0 | 6 (1) |
| Other | 2 (<1) | 2 (1) | 0 | 4 (<1) |
| Donor age | ||||
| Mean (standard deviation) | 57 (15) | 58 (15) | 60 (11) | 59 (13) |
| <66 | 239 (69) | 115 (59) | 39 (71) | 314 (64) |
| ≥66 | 108 (31) | 79 (41) | 16 (29) | 180 (36) |
| Current cigarette smoker | 20 (6) | 19 (10) | 3 (5) | 60 (12) |
| Use of glaucoma medications at baseline | 22 (6) | 21 (11) | 15 (27) | 86 (17) |
| Prior glaucoma surgery | 14 (4) | 7 (4) | 14 (25) | 36 (7) |
| Diagnosis | ||||
| Fuchs’ dystrophy | 264 (76) | 112 (58) | 18 (33) | 282 (57) |
| Pseudophakic/aphakic corneal edema | 72 (21) | 73 (38) | 34 (62) | 190 (38) |
| Other | 11 (3) | 9 (5) | 3 (5) | 22 (4) |
| Preoperative lens status | ||||
| Phakic | 205 (59) | 76 (39) | 10 (18) | 199 (40) |
| Pseudophakic | 126 (36) | 103 (53) | 42 (76) | 263 (53) |
| Aphakic | 16 (5) | 15 (8) | 3 (5) | 32 (6) |
| Postoperative lens status | ||||
| Phakic | 69 (20) | 26 (13) | 4 (7) | 63 (13) |
| Pseudophakic | 270 (78) | 164 (85) | 48 (87) | 413 (84) |
| Aphakic | 8 (2) | 4 (2) | 3 (5) | 18 (4) |
| Baseline cell density* (cells/mm2) | ||||
| Mean (standard deviation) | 2690 (296) | 2667 (337) | 2644 (257) | 2662 (279) |
| Median (interquartile range) | 2698 (2481–2895) | 2665 (2435–2894) | 2634 (2478–2840) | 2651 (2464–2857) |
| <2300 | 25 (7) | 21 (11) | 4 (7) | 37 (7) |
| 2300–2499 | 69 (20) | 43 (22) | 11 (20) | 108 (22) |
| 2500–2699 | 80 (23) | 39 (20) | 17 (31) | 134 (27) |
| 2700–2899 | 90 (26) | 46 (24) | 12 (22) | 118 (24) |
| 2900–3099 | 53 (15) | 24 (12) | 11 (20) | 69 (14) |
| 3100–3300 | 23 (7) | 16 (8) | 0 | 21 (4) |
| >3300 | 7 (2) | 5 (3) | 0 | 7 (1) |
N (%) unless otherwise specified.
*
Includes density from eye bank for 432 eyes and from reading center for 658 eyes.